Tyr307
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Home > Phosphorylation Site Page: > Tyr307  -  PPP2CA (rat)

Site Information
VTRRTPDyFl_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448571

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 9 ) , phospho-antibody ( 1 , 6 , 7 , 8 , 9 , 10 , 11 ) , western blotting ( 1 , 6 , 7 , 8 , 9 , 11 )
Disease tissue studied:
Alzheimer's disease ( 10 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 8 ) , 'brain, hippocampus' ( 6 , 7 , 8 , 9 ) , 'brain, hypothalamus' ( 8 ) , 'brain, striatum' ( 11 ) , 'neuron, cerebellar granule'-brain ( 10 ) , 'neuron, cortical' ( 1 ) , SKNSH (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
GBA (human) ( 1 )
Treatments:
anoxia ( 10 ) , C2-ceramide ( 1 ) , calyculin_A ( 7 ) , DHPG ( 11 ) , estradiol ( 8 ) , folic acid ( 9 ) , homocysteine ( 6 , 9 ) , hypoxia ( 3 ) , melatonin ( 7 ) , MPEP ( 11 ) , PP2 ( 11 ) , progesterone ( 8 ) , vitamin_B12 ( 9 ) , Zn(2+) ( 5 )

Downstream Regulation
Effects of modification on PPP2CA:
enzymatic activity, inhibited ( 1 , 7 ) , molecular association, regulation ( 9 )
Effects of modification on biological processes:
autophagy, inhibited ( 1 ) , translation, induced ( 1 )
Inhibit interaction with:
PPP2CB (rat) ( 9 )

References 

1

Du TT, et al. (2015) GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 11, 1803-20
26378614   Curated Info

2

Chai GS, et al. (2014) Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull 30, 923-35
25391447   Curated Info

3

Zhang CE, et al. (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14, 107-16
24993525   Curated Info

4

Yang W, et al. (2013) Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex. Neurochem Int 63, 180-94
23796501   Curated Info

5

Xiong Y, et al. (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34, 745-56
22892311   Curated Info

6

Chai GS, et al. (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124, 388-96
23157378   Curated Info

7

Yang X, et al. (2011) Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol 25, 1118-25
20542922   Curated Info

8

Amorim MA, et al. (2010) Progesterone regulates the phosphorylation of protein phosphatases in the brain. J Neurosci Res 88, 2826-32
20568292   Curated Info

9

Zhang CE, et al. (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-65
17537547   Curated Info

10

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

11

Mao L, et al. (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-10
15661743   Curated Info