Ser346
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Home > Phosphorylation Site Page: > Ser346  -  HIP (human)

Site Information
AQNPANMskYQsNPk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21006300

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , E.coli (bacterial) ( 1 )

Upstream Regulation
Regulatory protein:
CXCR4 (human) ( 1 )
Putative in vivo kinases:
GRK5 (human) ( 1 )
Kinases, in vitro:
GRK5 (human) ( 1 )

Downstream Regulation
Effects of modification on HIP:
receptor internalization, induced ( 1 )
Effects of modification on biological processes:
exocytosis, induced ( 1 )

References 

1

Barker BL, Benovic JL (2011) G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry 50, 6933-41
21728385   Curated Info