Ser1928
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Home > Phosphorylation Site Page: > Ser1928  -  CACNA1C (rabbit)

Site Information
ASLGRRAsFHLECLK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455278

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 4 ) , mutation of modification site ( 2 , 3 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 7 ) , western blotting ( 1 , 2 , 3 , 4 , 7 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 3 , 4 , 5 , 7 ) , myocyte ( 1 ) , myocyte-heart ( 7 ) , tsA201 (epithelial) ( 2 , 6 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 6 , 7 ) , PKCA (human) ( 7 ) , PKCB (human) ( 3 ) , PKG1 (human) ( 4 )
Kinases, in vitro:
PKACA (human) ( 7 ) , PKCA (human) ( 3 , 7 ) , PKCB (human) ( 3 ) , PKCB iso2 (human) ( 3 ) , PKCD (human) ( 3 ) , PKCE (human) ( 3 ) , PKCG (human) ( 3 ) , PKCT (human) ( 3 ) , PKCZ (human) ( 3 ) , PKG1 (cow) ( 4 ) , PRKD1 (human) ( 3 )
Treatments:
bisindolylmaleimide ( 7 ) , calyculin_A ( 4 , 7 ) , cGMP_analog ( 4 ) , colforsin ( 2 ) , H-89 ( 4 , 5 , 7 ) , ionomycin ( 2 ) , KT5823 ( 1 ) , okadaic_acid ( 2 ) , ouabain ( 1 ) , phorbol_ester ( 3 , 7 ) , SSA412 ( 1 )

Downstream Regulation
Effects of modification on CACNA1C:
activity, induced ( 1 ) , activity, inhibited ( 5 )

References 

1

Xu KY, Zhu W, Xiao RP (2010) Serine(496) of β(2) subunit of L-type Ca(2+) channel participates in molecular crosstalk between activation of (Na(+)+K(+))-ATPase and the channel. Biochem Biophys Res Commun 402, 319-23
20937253   Curated Info

2

Fuller MD, et al. (2010) Molecular mechanism of calcium channel regulation in the fight-or-flight response. Sci Signal 3, ra70
20876873   Curated Info

3

Yang L, et al. (2009) Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry 48, 6674-83
19527072   Curated Info

4

Yang L, et al. (2007) Protein kinase G phosphorylates Cav1.2 alpha1c and beta2 subunits. Circ Res 101, 465-74
17626895   Curated Info

5

Crump SM, et al. (2006) L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current. Am J Physiol Heart Circ Physiol 291, H1959-71
16648185   Curated Info

6

Wang M, Berlin JR (2006) Channel phosphorylation and modulation of L-type Ca2+ currents by cytosolic Mg2+ concentration. Am J Physiol Cell Physiol 291, C83-92
16481369   Curated Info

7

Yang L, et al. (2005) Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. J Biol Chem 280, 207-14
15509562   Curated Info