Ser1897
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Home > Phosphorylation Site Page: > Ser1897  -  CACNA1C (mouse)

Site Information
ASLGRRAsFHLECLK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455278

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 6 ) , phospho-antibody ( 2 , 5 , 6 , 7 ) , western blotting ( 1 , 2 , 5 , 6 , 7 )
Disease tissue studied:
CS ( 2 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 ) , brain ( 7 ) , heart ( 4 , 5 , 6 ) , myocyte-heart ( 2 , 6 )

Upstream Regulation
Regulatory protein:
AKAP5 (mouse) ( 7 )
Putative in vivo kinases:
PKACA (rat) ( 7 ) , PKCA (human) ( 5 )
Kinases, in vitro:
PKACA (human) ( 6 )
Treatments:
isoproterenol ( 1 , 7 ) , propranolol ( 7 )

Downstream Regulation
Effects of modification on CACNA1C:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Inhibit interaction with:
ADRB2 (mouse) ( 1 )

References 

1

Patriarchi T, et al. (2016) Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. EMBO J 35, 1330-45
27103070   Curated Info

2

Levin MD, et al. (2016) KATP channel gain-of-function leads to increased myocardial L-type Ca2+ current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A 113, 6773-8
27247394   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

5

Yang L, et al. (2009) Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c). Biochemistry 48, 6674-83
19527072   Curated Info

6

Lemke T, et al. (2008) Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. J Biol Chem 283, 34738-44
18829456   Curated Info

7

Hall DD, et al. (2007) Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons. Biochemistry 46, 1635-46
17279627   Curated Info