Thr290
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Home > Phosphorylation Site Page: > Thr290  -  Cot (mouse)

Site Information
LPKDLRGtEIYMSPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455276

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , HEK293T (epithelial) ( 1 ) , macrophage-blood ( 3 ) , PK-15 (epithelial) ( 1 ) , RAW 264 (macrophage) [Cot (mouse)] ( 2 ) , RAW 264 (macrophage) ( 3 )

Upstream Regulation
Regulatory protein:
Cot (mouse) ( 2 )
Putative in vivo kinases:
IKKB (mouse) ( 3 )
Treatments:
LPS ( 2 , 3 ) , PS-1145 ( 3 ) , siRNA ( 3 ) , TNF ( 3 ) , virus infection ( 1 )

Downstream Regulation
Effects of modification on Cot:
enzymatic activity, induced ( 1 , 3 ) , intracellular localization ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, induced ( 1 )

References 

1

Hao J, et al. (2020) Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication. Front Immunol 11, 580334
33488582   Curated Info

2

Robinson MJ, et al. (2007) Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol Cell Biol 27, 7355-64
17709378   Curated Info

3

Cho J, Melnick M, Solidakis GP, Tsichlis PN (2005) Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem 280, 20442-8
15778223   Curated Info