Ser1346

Site Information
QPLsKSSsSPELQTL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 450212

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , C2C12 (myoblast) ( 1 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on TSC2 iso2:	phosphorylation ( 1 , 2 )
Effects of modification on biological processes:	apoptosis, altered ( 2 ) , cell growth, altered ( 2 )

References
1	Wang C, et al. (2007) Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem 282, 7991-6 17244624 Curated Info
2	Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-90 14651849 Curated Info