Ser1346
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Home > Phosphorylation Site Page: > Ser1346  -  TSC2 iso2 (rat)

Site Information
QPLsKSSsSPELQTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450212

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 2 )
Kinases, in vitro:
AMPKA1 (human) ( 2 )
Treatments:
2-deoxyglucose ( 2 )

Downstream Regulation
Effects of modification on TSC2 iso2:
phosphorylation ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , cell growth, altered ( 2 )

References 

1

Wang C, et al. (2007) Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem 282, 7991-6
17244624   Curated Info

2

Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-90
14651849   Curated Info