Thr89
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Home > Phosphorylation Site Page: > Thr89  -  PLM (rat)

Site Information
SsIRRLstRRR____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455220

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
heart ( 2 ) , myocyte-heart ( 2 , 3 ) , oocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 3 )
Treatments:
endothelin ( 3 ) , inhibitor-1 ( 2 ) , isoproterenol ( 2 ) , okadaic_acid ( 2 ) , phenylephrine ( 3 ) , phorbol_ester ( 3 )

Downstream Regulation
Effects of modification on PLM:
activity, induced ( 3 ) , intracellular localization ( 1 )

References 

1

Moshitzky S, Asher C, Garty H (2012) Intracellular Trafficking of FXYD1 (Phospholemman) and FXYD7 Proteins in Xenopus Oocytes and Mammalian Cells. J Biol Chem 287, 21130-41
22535957   Curated Info

2

El-Armouche A, et al. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB J 25, 4467-75
21849407   Curated Info

3

Fuller W, et al. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol 296, C1346-55
19339511   Curated Info