Ser205
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Home > Phosphorylation Site Page: > Ser205  -  AA-NAT (sheep)

Site Information
HAALRRNsDR_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452142

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
CHO-K1 (fibroblast) ( 2 ) , pineal gland ( 3 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 1 , 3 )
Treatments:
light ( 3 )

Downstream Regulation
Effects of modification on AA-NAT:
enzymatic activity, inhibited ( 1 , 3 ) , molecular association, regulation ( 1 , 2 ) , protein stabilization ( 2 )
Induce interaction with:
14-3-3 beta (human) ( 2 ) , 14-3-3 zeta (sheep) ( 1 , 3 )

References 

1

Szewczuk LM, et al. (2008) Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry 47, 10407-19
18771288   Curated Info

2

Zheng W, et al. (2005) Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. J Biol Chem 280, 10462-7
15632116   Curated Info

3

Ganguly S, et al. (2005) Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A 102, 1222-7
15644438   Curated Info

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