Ser120
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser120  -  SNAP23 (mouse)

Site Information
NVVskQPsRITNGQP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455263

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mutation of modification site ( 2 , 5 ) , phospho-antibody ( 1 , 3 , 5 ) , western blotting ( 1 , 2 , 3 , 5 )
Relevant cell line - cell type - tissue:
BMMC (mast) ( 3 ) , dendritic cell ( 2 ) , hepatic ( 5 ) , macrophage-bone marrow ( 4 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 4 ) , mast ( 1 )

Upstream Regulation
Regulatory protein:
CAPN1 (mouse) ( 3 ) , IKKB (human) ( 1 ) , MYD88 (human) ( 2 ) , TLR1 (human) ( 2 )
Putative in vivo kinases:
IKKB (mouse) ( 2 , 5 )
Kinases, in vitro:
IKKB (human) ( 5 )
Treatments:
DNP ( 1 ) , IgE ( 5 ) , LPS ( 2 ) , TNP ( 3 ) , TPCA1 ( 2 )

Downstream Regulation
Effects of modification on SNAP23:
protein stabilization ( 2 )
Effects of modification on biological processes:
exocytosis, altered ( 5 ) , exocytosis, induced ( 1 )

References 

1

Peschke K, et al. (2014) IκB Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation. Cell Rep 8, 1300-7
25176657   Curated Info

2

Nair-Gupta P, et al. (2014) TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation. Cell 158, 506-21
25083866   Curated Info

3

Wu Z, et al. (2014) Calpain-1 contributes to IgE-mediated mast cell activation. J Immunol 192, 5130-9
24760147   Curated Info

4

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

5

Suzuki K, Verma IM (2008) Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 134, 485-95
18692471   Curated Info