Ser95
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Home > Phosphorylation Site Page: > Ser95  -  SNAP23 (human)

Site Information
NRTkNFEsGkAykTt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455262

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mass spectrometry ( 3 , 4 ) , mass spectrometry (in vitro) ( 5 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 1 ) , PKM (human) ( 3 )
Kinases, in vitro:
PKCA (rat) ( 5 ) , PKM (human) ( 3 )
Treatments:
ceruletide ( 2 ) , phorbol_ester ( 1 ) , thrombin ( 2 )

Downstream Regulation
Effects of modification on SNAP23:
protein conformation ( 1 , 3 )
Effects of modification on biological processes:
endocytosis, inhibited ( 1 ) , exocytosis, induced ( 3 )

References 

1

Sakurai C, et al. (2018) Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages. Mol Biol Cell, mbcE17080523
29771640   Curated Info

2

Zhang J, et al. (2018) Dynamic Cycling of t-SNARE Acylation Regulates Platelet Exocytosis. J Biol Chem
29352103   Curated Info

3

Wei Y, et al. (2017) Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nat Commun 8, 14041
28067230   Curated Info

4

Zhou J (2009) CST Curation Set: 6054; Year: 2009; Biosample/Treatment: cell line, Jurkat/TPA; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M)
Curated Info

5

Polgár J, et al. (2003) Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem 278, 44369-76
12930825   Curated Info