Ser120
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Home > Phosphorylation Site Page: > Ser120  -  SNAP23 (rat)

Site Information
NVVsKQPsRITNGQP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455263

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 2 ) , glioma ( 2 ) , leukemia ( 1 )
Relevant cell line - cell type - tissue:
astrocyte ( 2 ) , C6 (glial) ( 2 ) , platelet-blood ( 3 ) , RBL-2H3 (basophil) [SNAP23 (rat)] ( 3 ) , RBL-2H3 (basophil) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (rat) ( 2 , 3 )
Treatments:
antigenic stimulation ( 3 ) , bisindolylmaleimide ( 2 , 3 ) , phorbol_ester ( 2 ) , thrombin ( 3 )

Downstream Regulation
Effects of modification on SNAP23:
intracellular localization ( 1 )
Effects of modification on biological processes:
exocytosis, altered ( 2 ) , exocytosis, inhibited ( 1 )

References 

1

Naskar P, Naqvi N, Puri N (2018) Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells. J Biosci 43, 127-138
29485121   Curated Info

2

Yasuda K, et al. (2011) PKC-dependent inhibition of CA(2+) -dependent exocytosis from astrocytes. Glia 59, 143-51
20967886   Curated Info

3

Hepp R, et al. (2005) Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem 280, 6610-20
15611044   Curated Info