Ser120
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Home > Phosphorylation Site Page: > Ser120  -  SNAP23 (rat)

Site Information
NVVsKQPsRITNGQP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455263

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 5 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Disease tissue studied:
brain cancer ( 4 ) , glioma ( 4 ) , leukemia ( 3 ) , pancreatic cancer ( 1 , 2 ) , pancreatic carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
AR42J (pancreatic) ( 2 ) , astrocyte ( 4 ) , C6 (glial) ( 4 ) , HEK293T (epithelial) ( 1 ) , INS-1 (pancreatic) ( 1 ) , pancreatic acini ( 2 ) , platelet-blood ( 5 ) , RBL-2H3 (basophil) [SNAP23 (rat)] ( 5 ) , RBL-2H3 (basophil) ( 3 )

Upstream Regulation
Putative in vivo kinases:
IKKB (rat) ( 2 ) , PKCA (rat) ( 4 , 5 )
Treatments:
antigenic stimulation ( 5 ) , Bay_11-7082 ( 2 ) , bisindolylmaleimide ( 4 , 5 ) , BMS-345541 ( 2 ) , cholecystokinin ( 2 ) , ethanol ( 2 ) , phorbol_ester ( 4 ) , thrombin ( 5 )

Downstream Regulation
Effects of modification on SNAP23:
intracellular localization ( 2 , 3 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
exocytosis, altered ( 4 ) , exocytosis, inhibited ( 3 )
Induce interaction with:
STX17 (rat) ( 2 )

References 

1

Chen J, et al. (2023) SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A. Biosci Rep 43
37057886   Curated Info

2

Dolai S, et al. (2020) Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes. Autophagy, 1-14
33213278   Curated Info

3

Naskar P, Naqvi N, Puri N (2018) Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells. J Biosci 43, 127-138
29485121   Curated Info

4

Yasuda K, et al. (2011) PKC-dependent inhibition of CA(2+) -dependent exocytosis from astrocytes. Glia 59, 143-51
20967886   Curated Info

5

Hepp R, et al. (2005) Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem 280, 6610-20
15611044   Curated Info

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