Ser381
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Home > Phosphorylation Site Page: > Ser381  -  TNF-R1 (human)

Site Information
FVRRLGLsDHEIDRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20831307

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , [32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 ) , lymphoma ( 1 ) , Burkitt's lymphoma ( 1 )
Relevant cell line - cell type - tissue:
Daudi (B lymphocyte) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , MEF (fibroblast) ( 1 ) , splenocyte ( 1 ) , thymocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 1 )
Kinases, in vitro:
IKKB (human) ( 1 )
Treatments:
PS-1145 ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on TNF-R1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
TRADD (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
colonic inflamation ( 1 ) , Crohn disease ( 1 )

References 

1

Guan YJ, et al. (2011) Phospho-SXXE/D Motif Mediated TNF Receptor 1-TRADD Death Domain Complex Formation for T Cell Activation and Migration. J Immunol 187, 1289-97
21724995   Curated Info