Ser1900
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Home > Phosphorylation Site Page: > Ser1900  -  Notch 1 (human)

Site Information
GGLEtGNsEEEEDAP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20831302

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:
HC11 (epithelial) ( 2 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 2 ) , hematopoietic progenitor-bone marrow ( 1 ) , NCI-H1299 (pulmonary) ( 2 ) , Sf21 ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 )
Treatments:
TBCA ( 2 )

Downstream Regulation
Effects of modification on Notch 1:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
transcription, induced ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
RBPJ (human) ( 1 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Cheng P, et al. (2014) Effects of notch signaling on regulation of myeloid cell differentiation in cancer. Cancer Res 74, 141-52
24220241   Curated Info

2

Ranganathan P, et al. (2011) Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity. J Biol Chem 286, 28844-57
21685388   Curated Info