Ser227
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Home > Phosphorylation Site Page: > Ser227  -  PEDF (human)

Site Information
KFDSRKTsLEDFYLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455233

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
BAEC (endothelial) ( 1 ) , COS (fibroblast) ( 1 ) , HUVEC (endothelial) ( 1 ) , MDA-MB-231 (breast cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on PEDF:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 1 ) , carcinogenesis, altered ( 1 ) , cell motility, altered ( 1 )
Induce interaction with:
LEPR (human) ( 1 )

References 

1

Konson A, Pradeep S, D'Acunto CW, Seger R (2011) Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. J Biol Chem 286, 3540-51
21059648   Curated Info

2

Maik-Rachline G, Shaltiel S, Seger R (2005) Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood 105, 670-8
15374885   Curated Info