Thr379
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Home > Phosphorylation Site Page: > Thr379  -  MOR-1 (mouse)

Site Information
EHPstANtVDRTNHQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20727900

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 6 ) , mutation of modification site ( 6 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 3 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 , 6 ) , brain ( 3 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (human) ( 2 ) , GRK3 (human) ( 2 )
Treatments:
DAMGO ( 2 , 4 ) , etonitazene ( 3 ) , fentanyl ( 3 ) , morphine ( 2 , 3 , 6 ) , mutation ( 3 ) , phorbol_ester ( 4 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on MOR-1:
molecular association, regulation ( 2 ) , receptor desensitization, induced ( 2 ) , receptor internalization, induced ( 6 )
Effects of modification on biological processes:
endocytosis, induced ( 2 , 6 )
Induce interaction with:
ARRB2 (human) ( 2 )

References 

1

Gillis A, et al. (2020) Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists. Sci Signal 13
32234959   Curated Info

2

Miess E, et al. (2018) Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization. Sci Signal 11
30018083   Curated Info

3

Glück L, et al. (2014) Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5. Biol Psychiatry 76, 767-74
24629717   Curated Info

4

Illing S, Mann A, Schulz S (2014) Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C. Br J Pharmacol 171, 1330-40
24308893   Curated Info

5

Just S, et al. (2013) Differentiation of opioid drug effects by hierarchical multi-site phosphorylation. Mol Pharmacol 83, 633-9
23239825   Curated Info

6

Lau EK, et al. (2011) Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci Signal 4, ra52
21868358   Curated Info