Thr191
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Home > Phosphorylation Site Page: > Thr191  -  NUDE1 (human)

Site Information
QKQEKPRtPMPSSVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20722719

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 6 ) , mass spectrometry ( 1 , 3 , 4 , 5 ) , mutation of modification site ( 2 , 6 ) , western blotting ( 2 , 6 )
Disease tissue studied:
breast cancer ( 4 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 2 )
Kinases, in vitro:
CDK1 (human) ( 6 )

Downstream Regulation
Effects of modification on NUDE1:
intracellular localization ( 2 , 6 ) , molecular association, regulation ( 2 , 6 ) , protein degradation ( 2 )
Induce interaction with:
FBXW7 (human) ( 2 )
Inhibit interaction with:
ZNF365 (human) ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Maskey D, et al. (2015) Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J 34, 2424-40
26206584   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

6

Hirohashi Y, et al. (2006) Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Oncogene 25, 6048-55
16682949   Curated Info