Thr704
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Home > Phosphorylation Site Page: > Thr704  -  ARHGEF7 (human)

Site Information
EFAsRkstAALEEDA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455216

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 ) , lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 2 ) , Jurkat (T lymphocyte) ( 3 ) , lung ( 1 ) , PC-12 (chromaffin) ( 4 )

Upstream Regulation
Treatments:
FGF2 ( 4 ) , Y27632 ( 2 )

Downstream Regulation
Effects of modification on ARHGEF7:
activity, induced ( 4 ) , molecular association, regulation ( 4 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 4 )
Inhibit interaction with:
RAP1GDS1 (human) ( 4 )

References 

1

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

2

Nishioka T, Nakayama M, Amano M, Kaibuchi K (2012) Proteomic screening for Rho-kinase substrates by combining kinase and phosphatase inhibitors with 14-3-3ΞΆ affinity chromatography. Cell Struct Funct 37, 39-48
22251793   Curated Info

3

Guo A (2011) CST Curation Set: 12077; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTDXEAntibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) CK2 Substrate (P-S/T3-100) Rabbit mAb Cat#: 8738
Curated Info

4

Shin EY, et al. (2006) betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem 281, 35954-64
16954223   Curated Info

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