Thr526
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Home > Phosphorylation Site Page: > Thr526  -  ARHGEF7 (rat)

Site Information
EFAVRKStAALEEDA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455216

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PAK1 (human) ( 2 ) , PKACA (human) ( 2 , 3 )
Treatments:
cAMP_analog ( 3 ) , colforsin ( 1 ) , endothelin ( 3 )

Downstream Regulation
Effects of modification on ARHGEF7:
intracellular localization ( 3 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )
Induce interaction with:
14-3-3 beta (human) ( 1 )

References 

1

Chahdi A, Sorokin A (2008) Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol 28, 1679-87
18160719   Curated Info

2

Saneyoshi T, et al. (2008) Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron 57, 94-107
18184567   Curated Info

3

Chahdi A, Miller B, Sorokin A (2005) Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem 280, 578-84
15513924   Curated Info