Tyr153
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Home > Phosphorylation Site Page: > Tyr153  -  CD3Z (mouse)

Site Information
sTATKDtyDALHMQT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455204

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
CD4+ (T lymphocyte) ( 1 ) , CD8+ (T lymphocyte) ( 1 ) , HEK293T (epithelial) ( 2 ) , spleen ( 3 )

Upstream Regulation
Regulatory protein:
CD3Z (mouse) ( 1 )
Putative in vivo kinases:
Lck (mouse) ( 2 )
Kinases, in vitro:
Lck (human) ( 2 )
Treatments:
antibody ( 1 )

References 

1

Gaud G, et al. (2023) CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. Nat Immunol 24, 2121-2134
37945821   Curated Info

2

Gelkop S, et al. (2012) Development of unique antibodies directed against each of the six different phosphotyrosine residues within the T cell receptor CD3ζ chain. J Immunol Methods 375, 129-37
22020291   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info