Tyr150
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Home > Phosphorylation Site Page: > Tyr150  -  WAVE2 (mouse)

Site Information
GKEALKFyTNPSyFF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455197

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , 3T3 (fibroblast) ( 2 ) , COS7 (fibroblast) ( 1 ) , neuron-'brain, cerebral cortex' ( 1 )

Upstream Regulation
Regulatory protein:
Abi-1 (mouse) ( 2 ) , Abi-2 (human) ( 1 )
Putative in vivo kinases:
Abl (mouse) ( 1 , 2 )
Treatments:
PDGF ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, induced ( 1 ) , cytoskeletal reorganization ( 2 )

References 

1

Xie MJ, et al. (2013) WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Cereb Cortex 23, 1410-23
22617848   Curated Info

2

Stuart JR, Gonzalez FH, Kawai H, Yuan ZM (2006) c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem 281, 31290-7
16899465   Curated Info