Thr117
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Home > Phosphorylation Site Page: > Thr117  -  Survivin (human)

Site Information
kNkIAkEtNNkkkEF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450947

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 )
Kinases, in vitro:
AurB (human) ( 2 )

Downstream Regulation
Effects of modification on Survivin:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )
Induce interaction with:
INCENP (human) ( 2 )

References 

1

Wheatley SP, et al. (2007) Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle 6, 1220-30
17457057   Curated Info

2

Wheatley SP, et al. (2004) Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem 279, 5655-60
14610074   Curated Info