Lys57
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Home > Acetylation Site Page: > Lys57  -  SIRT3 (mouse)

Site Information
GGGSSEKkFSLQDVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 206219718

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 ) , Hepa-1c1c7 (hepatic) ( 1 ) , hepatocyte ( 1 ) , liver ( 1 )

Downstream Regulation
Effects of modification on SIRT3:
acetylation ( 1 ) , enzymatic activity, inhibited ( 1 ) , protein degradation ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
liver disease ( 1 ) , NAFLD ( 1 ) , obesity, hyperphagic ( 1 )

References 

1

Kwon S, et al. (2017) Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3. J Biol Chem 292, 17312-17323
28808064   Curated Info