Ser45
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Home > Phosphorylation Site Page: > Ser45  -  AP2M1 (rat)

Site Information
HARQQVRsPVTNIAR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2048345

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 293 (epithelial) ( 1 ) , brain ( 1 ) , dorsal root ganglia ( 1 )

Upstream Regulation
Regulatory protein:
CDK5R1 (human) ( 1 )
Putative in vivo kinases:
CDK5 (rat) ( 1 )
Kinases, in vitro:
CDK5 (rat) ( 1 )
Treatments:
peptide inhibitor ( 1 ) , seliciclib ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on AP2M1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Inhibit interaction with:
TRPV1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hyperalgesia ( 1 )

References 

1

Liu J, Du J, Wang Y (2019) CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal 12
31186372   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info