Thr85
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Home > Phosphorylation Site Page: > Thr85  -  SMN (human)

Site Information
NKsQKkNtAAsLQQW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 20503415

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 ) , mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 2 , 4 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 4 ) , HeLa (cervical) ( 1 , 2 , 3 , 5 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 4 )

Downstream Regulation
Effects of modification on SMN:
intracellular localization ( 2 ) , molecular association, regulation ( 2 , 4 )
Induce interaction with:
coilin (human) ( 2 )
Inhibit interaction with:
GEMIN8 (human) ( 4 ) , SIP1 (human) ( 4 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Husedzinovic A, et al. (2014) Phosphoregulation of the human SMN complex. Eur J Cell Biol 93, 106-17
24602413   Curated Info

3

Grosstessner-Hain K, et al. (2011) Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics 10, M111.008540
21857030   Curated Info

4

Wu CY, et al. (2011) Identification of the phosphorylation sites in the survival motor neuron protein by protein kinase A. Biochim Biophys Acta 1814, 1134-9
21609790   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

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