Thr342
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Home > Phosphorylation Site Page: > Thr342  -  IRAK4 (human)

Site Information
AsEkFAQtVMtsRIV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2045344

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 4 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 2 , 4 )
Relevant cell line - cell type - tissue:
fibroblast-skin [IRAK4 (human), homozygous knockout] ( 2 ) , HEK293T (epithelial) ( 4 )

Upstream Regulation
Putative in vivo kinases:
IRAK4 (human) ( 4 )
Kinases, in vitro:
IRAK4 (human) ( 2 , 4 )

Downstream Regulation
Effects of modification on IRAK4:
enzymatic activity, induced ( 3 , 4 )

References 

1

Ferrao R, et al. (2014) IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly. Mol Cell 55, 891-903
25201411   Curated Info

2

Cushing L, et al. (2014) Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner. J Biol Chem 289, 10865-75
24567333   Curated Info

3

Kuglstatter A, et al. (2007) Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations. J Immunol 178, 2641-5
17312103   Curated Info

4

Cheng H, et al. (2007) Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop. Biochem Biophys Res Commun 352, 609-16
17141195   Curated Info