Ser185
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Home > Phosphorylation Site Page: > Ser185  -  GSTP1 (human)

Site Information
SAYVGRLsARPkLkA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455118

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 2 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MGR3 (glial) ( 2 ) , RAW 264.7 (macrophage) ( 1 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Kinases, in vitro:
PKACA (cow) ( 2 ) , PKCA (human) ( 2 ) , PKCH (human) ( 2 )
Treatments:
GF109203X ( 1 ) , Go_6983 ( 1 ) , LPS ( 1 )

Downstream Regulation
Effects of modification on GSTP1:
activity, induced ( 2 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
HMGB1 (human) ( 1 )

References 

1

Zhou Y, et al. (2018) Glutathione-Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release. Front Immunol 9, 268
29520271   Curated Info

2

Lo HW, Antoun GR, Ali-Osman F (2004) The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Res 64, 9131-8
15604283   Curated Info

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