Ser43
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Home > Phosphorylation Site Page: > Ser43  -  GSTP1 (human)

Site Information
VETWQEGsLkAsCLy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455117

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 4 )
Disease tissue studied:
brain cancer ( 4 ) , glioblastoma ( 4 ) , glioma ( 4 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 3 ) , 293 (epithelial) ( 1 ) , breast ( 2 ) , MGR3 (glial) ( 4 ) , RAW 264.7 (macrophage) ( 1 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKCH (human) ( 4 )

Downstream Regulation
Effects of modification on GSTP1:
activity, induced ( 4 )

References 

1

Zhou Y, et al. (2018) Glutathione-Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release. Front Immunol 9, 268
29520271   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13
19664994   Curated Info

4

Lo HW, Antoun GR, Ali-Osman F (2004) The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Res 64, 9131-8
15604283   Curated Info

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