Tyr245
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Home > Phosphorylation Site Page: > Tyr245  -  NYAP2 (human)

Site Information
PEEEEPVyIEMVGNI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455101
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 5 , 6 , 7 , 8 ) , small-cell lung cancer ( 5 , 6 , 7 , 8 ) , neuroblastoma ( 1 , 4 ) , ovarian cancer ( 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain [NYAP2 (mouse), homozygous knockout] ( 2 ) , 293 (epithelial) ( 2 ) , DMS153 (pulmonary) ( 5 ) , NCI-H69 (pulmonary) ( 6 , 7 , 8 ) , OVKATE (ovarian) ( 3 ) , SKNFI (neural crest) ( 1 , 4 )

References 

1

Palacios-Moreno J, et al. (2015) Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts. PLoS Comput Biol 11, e1004130
25884760   Curated Info

2

Yokoyama K, et al. (2011) NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J 30, 4739-54
21946561   Curated Info

3

Ren H (2010) CST Curation Set: 10743; Year: 2010; Biosample/Treatment: cell line, OVKATE/serum starved; Disease: ovarian cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Stokes M (2006) CST Curation Set: 1764; Year: 2006; Biosample/Treatment: cell line, SKNFI/serum starved; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Farnsworth C (2004) CST Curation Set: 491; Year: 2004; Biosample/Treatment: cell line, DMS153/serum starved; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Farnsworth C (2004) CST Curation Set: 607; Year: 2004; Biosample/Treatment: cell line, NCI-H69/0.1% serum; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

7

Farnsworth C (2004) CST Curation Set: 608; Year: 2004; Biosample/Treatment: cell line, NCI-H69/-; Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Farnsworth C (2004) CST Curation Set: 609; Year: 2004; Biosample/Treatment: cell line, NCI-H69/SCF (stem cell factor); Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info