Thr1078
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Home > Phosphorylation Site Page: > Thr1078  -  CTNND2 (mouse)

Site Information
RPySSSRtPsIsPVR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2020381

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 3 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , brain ( 1 ) , MEF (fibroblast) ( 3 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 3 )
Kinases, in vitro:
GSK3B (human) ( 3 )

Downstream Regulation
Effects of modification on CTNND2:
protein degradation ( 3 ) , ubiquitination ( 3 )

References 

1

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

2

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

3

Oh M, et al. (2009) GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. J Biol Chem 284, 28579-89
19706605   Curated Info