Ser246
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Home > Phosphorylation Site Page: > Ser246  -  MDM2 (human)

Site Information
DsVsDQFsVEFEVEs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454925

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 ) , GM1604 (fibroblast) ( 1 ) , NCI-H1299 (pulmonary) ( 1 )

Downstream Regulation
Effects of modification on MDM2:
activity, induced ( 1 )

References 

1

Blattner C, Hay T, Meek DW, Lane DP (2002) Hypophosphorylation of Mdm2 augments p53 stability. Mol Cell Biol 22, 6170-82
12167711   Curated Info