Ser244
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Home > Phosphorylation Site Page: > Ser244  -  MDM2 (mouse)

Site Information
DsVsDQFsVEFEVES   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454925

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , COS (fibroblast) ( 1 ) , U2OS (bone cell) [GR (human)] ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1D (human) ( 1 , 2 )

References 

1

Kulikov R, Boehme KA, Blattner C (2005) Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. Mol Cell Biol 25, 7170-80
16055726   Curated Info

2

Winter M, et al. (2004) Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry 43, 16356-64
15610030   Curated Info