Ser240
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Home > Phosphorylation Site Page: > Ser240  -  MDM2 (human)

Site Information
GDWLDQDsVsDQFsV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454919

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 2 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK1D (human) ( 1 )
Treatments:
ionizing_radiation ( 2 )

Downstream Regulation
Effects of modification on MDM2:
activity, induced ( 2 )

References 

1

Inuzuka H, et al. (2010) Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell 18, 147-59
20708156   Curated Info

2

Blattner C, Hay T, Meek DW, Lane DP (2002) Hypophosphorylation of Mdm2 augments p53 stability. Mol Cell Biol 22, 6170-82
12167711   Curated Info