Tyr191

Site Information
SRRDGRKyPELVLDK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454910

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:	lung cancer ( 3 , 4 , 5 ) , non-small cell lung cancer ( 3 , 4 ) , small-cell lung cancer ( 5 ) , lymphoma ( 2 ) , B cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:	293 (epithelial) [FGFR1 (human), transfection, ZNF198-FGFR1 fusion protein] ( 1 ) , NCI-H1650 (pulmonary) ( 3 ) , NCI-H1975 (pulmonary) ( 4 ) , NCI-H526 (pulmonary) ( 5 ) , OCI-ly3 (B lymphocyte) ( 2 )

Upstream Regulation
Regulatory protein:	FGFR1 (human) ( 1 )

References
1	Kasyapa C, et al. (2009) Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS. Proteomics 9, 3979-88 19658100 Curated Info
2	Gu T (2004) CST Curation Set: 485; Year: 2004; Biosample/Treatment: cell line, OCI-ly3/-; Disease: B cell lymphoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Guo A (2004) CST Curation Set: 541; Year: 2004; Biosample/Treatment: cell line, NCI-H1650/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	Guo A (2004) CST Curation Set: 542; Year: 2004; Biosample/Treatment: cell line, NCI-H1975/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Farnsworth C (2004) CST Curation Set: 447; Year: 2004; Biosample/Treatment: cell line, NCI-H526/SCF (stem cell factor); Disease: small-cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info