Ser46

Site Information
PQPSRRGsDssEDIY SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 449320

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 ) , phosphopeptide mapping ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:	'muscle, skeletal' ( 1 , 2 ) , C2C12 (myoblast) ( 3 ) , CHO (fibroblast) [INSR (human)] ( 3 )

Upstream Regulation
Kinases, in vitro:	RSK2 (human) ( 3 )
Treatments:	insulin ( 3 )

References
1	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
2	Højlund K, et al. (2009) In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS. J Proteome Res 8, 4954-65 19764811 Curated Info
3	Liu J, Brautigan DL (2000) Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase. J Biol Chem 275, 15940-7 10748124 Curated Info