Ser116

Site Information
PRLYDRRsIFDAVAQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454886

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , CHO (fibroblast) ( 2 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 3 )

Downstream Regulation
Effects of modification on TRPV1:	receptor desensitization, altered ( 5 )

References
1	Spahn V, et al. (2013) Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain 154, 598-608 23398938 Curated Info
2	Por ED, Gomez R, Akopian AN, Jeske NA (2013) Phosphorylation regulates TRPV1 association with β-arrestin-2. Biochem J 451, 101-9 23360390 Curated Info
3	Mohapatra DP, Nau C (2005) Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 280, 13424-32 15691846 Curated Info
4	Wang Y, et al. (2004) Interaction between protein kinase Cmu and the vanilloid receptor type 1. J Biol Chem 279, 53674-82 15471852 Curated Info
5	Bhave G, et al. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35, 721-31 12194871 Curated Info