Ser450
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Home > Phosphorylation Site Page: > Ser450  -  DOK1 (human)

Site Information
sHNsALysQVQKSGA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454885

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
ataxia-telangiectasia ( 3 ) , lymphoma ( 3 ) , Burkitt's lymphoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATM (human) ( 3 )
Putative in vivo kinases:
IKKB (human) ( 3 )
Treatments:
anti-TNFalpha ( 3 ) , ionizing_radiation ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, inhibited ( 3 ) , cell motility, induced ( 3 )

References 

1

Mulhern D (2011) CST Curation Set: 12688; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Mulhern D (2011) CST Curation Set: 12696; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Lee S, et al. (2004) IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Proc Natl Acad Sci U S A 101, 17416-21
15574499   Curated Info