Ser439
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Home > Phosphorylation Site Page: > Ser439  -  DOK1 (human)

Site Information
EPGtATGsGIKsHNs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454882

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
ataxia-telangiectasia ( 1 ) , lymphoma ( 1 ) , Burkitt's lymphoma ( 1 )
Relevant cell line - cell type - tissue:
BJAB (B lymphocyte) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , lymphoblastoid ( 1 )

Upstream Regulation
Putative in vivo kinases:
IKKB (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , cell motility, induced ( 1 )

References 

1

Lee S, et al. (2004) IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Proc Natl Acad Sci U S A 101, 17416-21
15574499   Curated Info

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