Thr184
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Home > Phosphorylation Site Page: > Thr184  -  TAK1 (mouse)

Site Information
GTACDIQtHMtNNKG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454876

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 3 ) , 293 (epithelial) ( 1 ) , ES (stem) ( 1 ) , VSMC ('muscle, smooth') ( 2 )

Upstream Regulation
Regulatory protein:
LKB1 (mouse) ( 3 ) , PKCA (rat) ( 2 ) , TRAF6 (rat) ( 2 )
Treatments:
angiotensin_2 ( 2 ) , exercise ( 3 ) , NSC697923 ( 1 ) , SB431542 ( 1 ) , TGF-beta ( 1 )

References 

1

Charlaftis N, et al. (2014) The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J 33, 2581-96
25260751   Curated Info

2

Doyon P, Servant MJ (2010) Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. J Biol Chem 285, 30708-18
20659889   Curated Info

3

McGee SL, Mustard KJ, Hardie DG, Baar K (2008) Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586, 1731-41
18202101   Curated Info