Tyr478
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Home > Phosphorylation Site Page: > Tyr478  -  Ezrin (mouse)

Site Information
PPPPPPVyEPVNyHV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454875

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
breast cell-breast ( 2 ) , C2C12-D (muscle cell) ( 3 ) , lung ( 2 )

Upstream Regulation
Regulatory protein:
Src (mouse) ( 2 )
Putative in vivo kinases:
Src (human) ( 2 )
Putative upstream phosphatases:
PTPRS (mouse) ( 1 )
Phosphatases, in vitro:
PTPRS (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , cell growth, induced ( 2 ) , cell motility, induced ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 2 )

References 

1

Murchie R, et al. (2014) Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability. Proc Natl Acad Sci U S A 111, 693-8
24385580   Curated Info

2

Mak H, et al. (2012) Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells. BMC Cancer 12, 82
22397367   Curated Info

3

Guo A (2007) CST Curation Set: 2783; Year: 2007; Biosample/Treatment: cell line, C2C12-D/Insulin; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info