Lys315
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Home > Acetylation Site Page: > Lys315  -  NFkB-p65 (human)

Site Information
TFKSIMKkSPFSGPT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1985901

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 4 ) , mass spectrometry (in vitro) ( 4 ) , modification-specific antibody ( 1 , 3 , 4 ) , mutation of modification site ( 2 , 3 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
nicotinamide ( 4 ) , siRNA ( 2 ) , TNF ( 4 ) , trichostatin_A ( 2 , 4 ) , vorinostat ( 1 )

Downstream Regulation
Effects of modification on NFkB-p65:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, altered ( 4 ) , transcription, induced ( 1 ) , transcription, inhibited ( 2 , 3 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Gatla HR, et al. (2017) Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem 292, 5043-5054
28167529   Curated Info

2

Ziesché E, et al. (2013) The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res 41, 90-109
23087373   Curated Info

3

Rothgiesser KM, Fey M, Hottiger MO (2010) Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics 11, 22
20064247   Curated Info

4

Buerki C, et al. (2008) Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res 36, 1665-80
18263619   Curated Info