Ser130

Site Information
GLRQPsPsHDGsLsP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454707

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	leukemia ( 6 ) , chronic myelogenous leukemia ( 6 ) , lung cancer ( 2 , 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:	Calu 6 (pulmonary) ( 3 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 4 ) , Flp-In T-Rex-293 (epithelial) ( 4 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC2279 (pulmonary) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HOP62 (pulmonary) ( 3 ) , HUES-9 ('stem, embryonic') ( 5 ) , K562 (erythroid) ( 6 ) , liver ( 1 ) , lung ( 2 ) , NCI-H157 (pulmonary) ( 3 ) , NCI-H1648 (pulmonary) ( 3 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H2172 (pulmonary) ( 3 ) , NCI-H322 (pulmonary) ( 3 )

Upstream Regulation
Kinases, in vitro:	CAMK2A (human) ( 7 )

References
1	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
2	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
5	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
6	Stokes M (2008) CST Curation Set: 4390; Year: 2008; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]) Curated Info
7	Dubois T, et al. (2003) Novel in vitro and in vivo phosphorylation sites on protein phosphatase 1 inhibitor CPI-17. Biochem Biophys Res Commun 302, 186-92 12604330 Curated Info