Lys338

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Home > Ubiquitylation Site Page: > Lys338 - KOR-1 (human)

Site Information
AFLDENFkRCFRDFC SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1975302

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	CHO (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:	CYLD (human) ( 1 )
Treatments:	dynorphin_A ( 1 ) , U50488 ( 1 )

Downstream Regulation
Effects of modification on KOR-1:	protein degradation ( 1 ) , receptor internalization, induced ( 1 )

References
1	Li JG, Haines DS, Liu-Chen LY (2008) Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Mol Pharmacol 73, 1319-30 18212250 Curated Info

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