Lys734
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Home > Sumoylation Site Page: > Lys734  -  SIRT1 (human)

Site Information
INEAISVkQEVTDMN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1968605

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
H2O2 ( 1 ) , UV ( 1 )

Downstream Regulation
Effects of modification on SIRT1:
acetylation ( 1 ) , enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , transcription, inhibited ( 1 )

References 

1

Yang Y, et al. (2007) SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol 9, 1253-62
17934453   Curated Info