Lys451
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Home > Sumoylation Site Page: > Lys451  -  Tip60 (human)

Site Information
ISEITSIkKEDVIST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1968601

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 , 2 ) , HeLa (cervical) ( 2 ) , U2OS (bone cell) ( 2 )

Upstream Regulation
Treatments:
UV ( 2 )

Downstream Regulation
Effects of modification on Tip60:
enzymatic activity, induced ( 2 ) , intracellular localization ( 2 )
Effects of modification on biological processes:
DNA repair, induced ( 2 )

References 

1

Gao SS, et al. (2020) TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy. Sci Adv
32832608   Curated Info

2

Cheng Z, et al. (2008) Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response. Oncogene 27, 931-41
17704809   Curated Info

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