Thr187
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Home > Phosphorylation Site Page: > Thr187  -  TAK1 (mouse)

Site Information
CDIQtHMtNNKGsAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454704

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 5 ) , 293 (epithelial) ( 3 ) , ES (stem) ( 3 ) , keratinocyte-skin ( 2 ) , RAW 264.7 (macrophage) ( 1 ) , VSMC ('muscle, smooth') ( 4 )

Upstream Regulation
Regulatory protein:
LKB1 (mouse) ( 5 ) , PKCA (rat) ( 4 ) , TRAF6 (rat) ( 4 )
Treatments:
4-HT ( 2 ) , angiotensin_2 ( 4 ) , exercise ( 5 ) , IL-1b ( 2 ) , NSC697923 ( 3 ) , PUGNAc ( 1 ) , SB431542 ( 3 ) , TGF-beta ( 3 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on TAK1:
phosphorylation ( 1 )

References 

1

Zhang D, et al. (2016) Modification of TAK1 by O-linked N-acetylglucosamine facilitates TAK1 activation and promotes M1 macrophage polarization. Cell Signal 28, 1742-52
27542620   Curated Info

2

Hayashi K, et al. (2015) Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene 34, 4647-55
25486434   Curated Info

3

Charlaftis N, et al. (2014) The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J 33, 2581-96
25260751   Curated Info

4

Doyon P, Servant MJ (2010) Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. J Biol Chem 285, 30708-18
20659889   Curated Info

5

McGee SL, Mustard KJ, Hardie DG, Baar K (2008) Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586, 1731-41
18202101   Curated Info