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Site Information |
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CDIQtHMtNNKGsAA SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 454704 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on TAK1: | |
Effects of modification on biological processes: |
References | |
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Xu G, et al. (2022) HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer. Cell Death Dis 13, 888
36270986 Curated Info |
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Snelling T, et al. (2022) Coordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC. Biochem J
36098982 Curated Info |
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Ma S, et al. (2022) Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation. J Biol Chem, 102044
35595099 Curated Info |
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Yuan L, et al. (2022) EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma. Cell Death Differ
35105963 Curated Info |
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Singh AK, et al. (2021) Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system. Cell Mol Immunol 18, 162-170
31511642 Curated Info |
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Ke CY, Mei HH, Wong FH, Lo LJ (2019) IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion. Sci Signal 12
31387937 Curated Info |
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Ohshima J, et al. (2019) programs epithelial cells to resist ZEB2 induction by . Proc Natl Acad Sci U S A 116, 8544-8553
30971493 Curated Info |
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Zimmermann S, et al. (2017) ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System. Cell Rep 20, 2384-2395
28877472 Curated Info |
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Huang HL, Chiang CH, Hung WC, Hou MF (2015) Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. Oncotarget 6, 995-1007
25557171 Curated Info |
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Yang CY, et al. (2014) Dual-Specificity Phosphatase 14 (DUSP14/MKP6) Negatively Regulates TCR Signaling by Inhibiting TAB1 Activation. J Immunol 192, 1547-57
24403530 Curated Info |
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Pathak S, et al. (2012) O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. EMBO J 31, 1394-404
22307082 Curated Info |
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Bhattacharyya S, et al. (2011) Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-{kappa}B activation following carrageenan. Am J Physiol Gastrointest Liver Physiol 301, G475-86
21700900 Curated Info |
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Waiwut P, et al. (2011) Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. Mol Cell Biochem 350, 169-75
21188622 Curated Info |
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Hinz M, et al. (2010) A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Mol Cell 40, 63-74
20932475 Curated Info |
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Scholz R, et al. (2010) Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem 285, 25753-66
20538596 Curated Info |
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Shin MS, et al. (2009) Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1. Biochim Biophys Acta 1793, 1156-64
19393267 Curated Info |
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Jin HS, et al. (2009) cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. Cancer Res 69, 1782-91
19223549 Curated Info |
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Kim SI, Kwak JH, Wang L, Choi ME (2008) Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells. J Biol Chem 283, 10753-63
18299321 Curated Info |
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Morrison BH, et al. (2007) Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. J Biol Chem 282, 15349-56
17379600 Curated Info |
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Kajino T, et al. (2006) Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem 281, 39891-6
17079228 Curated Info |
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Thiefes A, et al. (2006) The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep 7, 838-44
16845370 Curated Info |
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Singhirunnusorn P, et al. (2005) Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 280, 7359-68
15590691 Curated Info |
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Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000) Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. FEBS Lett 474, 141-5
10838074 Curated Info |