Tyr219
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Home > Phosphorylation Site Page: > Tyr219  -  SHC3 iso2 (human)

Site Information
DGSDHPyyNSIPSKM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451258

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 2 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
EGFR (human) ( 2 ) , Src (human) ( 2 ) , TrkA (human) ( 2 ) , TrkB (human) ( 2 )

Downstream Regulation
Effects of modification on SHC3 iso2:
molecular association, regulation ( 2 )
Induce interaction with:
CRK (human) ( 2 ) , RAPGEF1 (human) ( 2 )

References 

1

Heinrich JN, et al. (2006) Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast. Cell Signal 18, 795-806
16126371   Curated Info

2

Nakamura T, et al. (2002) Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules. Oncogene 21, 22-31
11791173   Curated Info