Tyr304
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Home > Phosphorylation Site Page: > Tyr304  -  COX1 (cow)

Site Information
MDVDTRAyFTSATMI   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454437

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
hepatocyte-liver ( 3 ) , HepG2 (hepatic) ( 3 ) , liver ( 1 , 2 )

Upstream Regulation
Treatments:
NaF ( 1 ) , Theophylline ( 3 ) , TNF ( 2 ) , vanadate ( 1 )

Downstream Regulation
Effects of modification on COX1:
enzymatic activity, inhibited ( 2 , 3 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Hüttemann M, et al. (2012) Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim Biophys Acta 1817, 598-609
21771582   Curated Info

2

Samavati L, et al. (2008) Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem 283, 21134-44
18534980   Curated Info

3

Lee I, et al. (2005) cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity. J Biol Chem 280, 6094-100
15557277   Curated Info