Tyr67

Site Information
EHGsQGtySNTKENG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 454429

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 )
Disease tissue studied:	non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:	'brain, embryonic' ( 2 ) , COS (fibroblast) ( 2 ) , NCI-H3255 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:	Fyn (human) ( 2 )

Downstream Regulation
Effects of modification on MAP2:	molecular association, regulation ( 2 )
Induce interaction with:	GRB2 (human) ( 2 )

References
1	Rikova K (2012) CST Curation Set: 16146; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (SQ) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966 Curated Info
2	Zamora-Leon SP, Bresnick A, Backer JM, Shafit-Zagardo B (2005) Fyn phosphorylates human MAP-2c on tyrosine 67. J Biol Chem 280, 1962-70 15536091 Curated Info

References

Rikova K (2012) CST Curation Set: 16146; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
Curated Info

Zamora-Leon SP, Bresnick A, Backer JM, Shafit-Zagardo B (2005) Fyn phosphorylates human MAP-2c on tyrosine 67. J Biol Chem 280, 1962-70
15536091 Curated Info