Ser131
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Home > Phosphorylation Site Page: > Ser131  -  PARK2 (mouse)

Site Information
DTDSKRDsEAARGPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 454421

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, substantia nigra' ( 1 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Regulatory protein:
SNCA (mouse) ( 1 )
Putative in vivo kinases:
P38A (mouse) ( 1 )
Treatments:
SB203580 ( 1 )

Downstream Regulation
Effects of modification on PARK2:
enzymatic activity, inhibited ( 1 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )

References 

1

Bi M, et al. (2020) α-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models. ACS Chem Neurosci 11, 1682-1691
32379419   Curated Info

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